
Raman Spectroscopy - 785 & 532
Improved Signal from Suspended Solids
Overview
Blaze Raman Improves signal from dispersed phase solids. Depending on the conditions, the Blaze can substantially increase the solids (vs Liquid) signal captured dynamically in process. This enables users to better identify small volumes and/or track small changes in suspended particles such as polymorphs, solvates, hydrates, & particulate impurities; as well as better differentiate particle types in multiple component systems. A complement to Kaiser, Tornado, Wasatch and other Raman spectroscopy: The Blaze attaches directly to the Raman spectrometer, sending the Raman shifted light directly to the spectrometer. Spectrometers may be supplied via Blaze, directly from the Spectrometer Manufacture, or a pre-existing system at the user site. Spectroscopy systems are not created equal, please contact Blaze for optical match (Blaze-Spectrometer compatibility) and both hardware and software connectivity information for your spectrometer choice.
Blaze Raman: 9 Unique Features
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Critical Advanced Safety Features
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Improved Suspended Solids signal, often enabling
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Combined PAT for improved process understanding
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From using Blaze Turbidity to linearize the Raman Intensity signal improving precision of spectral transitions, to simply understanding window coating with Blaze Microscopy to understand its impact on Raman; combined technologies have many advantages.
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Both 532nm and 785nm Excited Raman capability in a single Probe
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Integration of both excitation sources enabling 400mW for 785nm out the window and advanced software integration.
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Software Enabling Alternating or Simultaneous Microscopy and Raman, where necessary, to avoid crosstalk between PAT.
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Optional Class 1M Raman vs the traditional 3B
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Optically Reduced Fluorescence, though minimal, at times can make a difference between success and failure
Disadvantages of using Blaze Raman Technology
9. A reduced signal due to the optical advantages that enable improved dispersed phase signal and reduced fluorescence.
Same API Slurry; Baseline-Corrected; Unsmoothed Spectra Expanded in Fingerprint Region (NOTE: Results are process dependent)
Blaze Particle Focused Raman vs Ball Probe


Blaze improved signal from suspended solids:
Kaiser probe liquid dominated signal:
Note Y Axis: Due to its excitation method and measurement zone, and the poor optical match with the standard Kaiser connection fibers used in this example above, Blaze has less overall signal with a much higher ratio of Raman from the solids. This has been improved with Kaiser's PhAT conduit connection to the Blaze channel. For dispersed phase systems, when Blaze has a good optical match with the spectrometer, the dispersed phase signal is often beyond that of other probes as shown below.
[Ypso Facto/MIT Webinar Link - Crystallization of Polymorphs: Advanced Process Monitoring, Data Analysis, and Mechanistic Modeling for Improved Process Understanding and Optimization]
BlazeMetrics Particle Focused Raman vs Kaiser MR10

BlazeMetrics In-Process Microscopy Images:

Next Generation Safety
785nm Laser Safety